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Nolva vs. Clomid for PCT
It seems like everyday questions concerning PCT pop up, and weather one should use either Clomid or nolva or a combo of both. I hope that this article written by BigCat may help to clear up some misconceptions.
While practically similar compounds in structure, few people ever really consider Clomid and nolva to be similar. Its not just a common myth in steroid circles, but even in the medical community. This misconception originates from their completely different uses. Nolvadex is most commonly used for the treatment of breast cancer in women, while Clomid is generally considered a fertility aid. In bodybuilding circles, from day one, Clomid has generally been used as post-cycle therapy and Nolvadex as an anti-estrogen.
But as I intend to demonstrate this is in essence the same. I believe the myth to have originated because nolva is clearly a more powerful anti-estrogen, and the people selling Clomid needed another angle to sell the stuff, so it was mostly used as a post-cycle aid. But few users really understand how Clomid (and also Nolvadex, logically) works to bring back natural testosterone in the body after the conclusion of a cycle of androgenic anabolic steroids. After a cycle is over, the level of androgens in the body drop drastically. The body compensates with an overproduction of estrogen to keep steroid levels up. Estrogen as well inhibits the production of natural testosterone, and in the period between the return of natural testosterone and the end of a cycle, a lot of mass is lost. So its in everybody's best interest to bring back natural test as soon as humanly possible. Clomid and Nolvadex will reduce the post-cycle estrogen, so that a steroid deficiency is constated and the hypothalamus is stimulated to regenerate natural testosterone production in the body. That's basically how the mechanism works, nothing more, nothing less.
Both compounds are structurally alike, classified as triphenylethylenes. Nolvadex is clearly the stronger component of the two as it can achieve better results in decreasing overall estrogen with 20-40 mg a day, than Clomid can in doses of 100-150 mg a day. A noteworthy difference. Triphenylethylenes are very mild estrogens that do not exert a lot, if any activity at the estrogen receptor, but are still highly attracted to it. As such they will occupy the receptor and keep it from binding estrogens. This means they do not actively work to reduce estrogen in the body like Proviron, Viratase or arimidex would (by competing for the aromatase enzyme), but that it blocks the receptor so that any estrogen in the body is basically inert, because it has no receptor to bind to.
This has advantages and disadvantages. The disadvantage is that when use is discontinued, the estrogen level is still the same and new problems will develop much sooner. The advantage is that it works much faster and has results sooner than with an aromatase blocker like Proviron or arimidex. Therefor, when problems such as gynocomastia occur during a cycle of steroids one will usually start 20 mg/day of nolva or 100 mg/day of Clomid straight away, in conjunction with some Proviron or arimidex. The proviron or arimidex will actively reduce estrogen while the Clomid or Nolvadex will solve your ongoing problem straight away. This way, when use is discontinued there is no immediate rebound.
So which one should you use? Well personally, I'd have to say Nolvadex. Both as an on-cycle anti-estrogen and a post-cycle therapy. As an anti-estrogen its simply much stronger, demonstrated by the fact that better results are obtained with 20-40 mg than with 100-150 mg of Clomid. For post-cycle, this plays a key role as well. It deactivates rebound estrogen much faster and more effective. But most importantly, Nolvadex has a direct influence on bringing back natural testosterone, where as Clomid may actually have a slight negative influence. The reason being that tamoxifen (as in Nolvadex) seems to increase the responsiveness of LH (luteinizing hormone) to GnRH (gonadtropin releasing hormone), whereas Clomid seems to decrease the responsiveness a bit1.
Another noteworthy fact about Nolvadex is that it acts more potently as an estrogen in the liver. As you remember, I mentioned that clomiphene and tamoxifen are basically weak estrogens. Well, tamoxifen is apparently still quite potent in the liver. This offers us the positive benefits of this hormone in the liver, while avoiding its negative effects elsewhere in the body. As such Nolvadex can have a very positive impact on negative cholesterol levels2 in the body, and therefore too should be considered a better choice than Clomid. It will not solve the problem of bad cholesterol levels during Steroid use, but will help to contain the problem to a larger degree.
Another reason why I promote the use of Nolvadex over Clomid post-cycle (as if being 3-4 times stronger and having more of a direct effect on restoring natural test wasn't enough) is because it's a lot safer. Not just because it improves lipid profiles, but also because it simply doesn't have the intrinsic side-effects that Clomid has. Clomid causes more acne for sure, but that's mainly because you need to use a 3-4 times higher dose. But Clomid seems to also affect the eyesight. Long-term Clomid therapy causes irreversible changes in eyesight3 in users. Irreversible. For me that alone is reason enough to prefer Nolvadex.
Lastly, one should be aware that use of these compounds can reduce the gains made on steroids. Nolvadex more so than Clomid, simply because it is stronger. Estrogen is responsible for a number of anabolic factors such as increasing growth hormone output, upgrading the androgen receptor and improving glucose utilization. This is why aromatizing steroids like testosterone are still best suited for maximum muscle gain. When reducing the estrogen levels, we therefore reduce the potential gains being made. For this reason one may opt to try Clomid during a cycle instead of Nolvadex. Although I would imagine that the problem that needed solved would be of more concern, in which case nolva remains the weapon of choice. It's a plain fact that there is a high correlation between gains and side-effects. Either you go for maximum gains and tolerate the side-effects, or you reduce the side-effects, and with it the gains. That's life, nothing is free.
Stacking and Use:
If problems of Gynocomastia or other estrogen related symptoms tend to pop up during a cycle the use of 20-30 mg of Nolvadex or 100 mg of Clomid daily should easily contain the problem, and be used until a few days after the problem subsides. For best results and the least amount of problems upon cessation it is best stacked with proviron (50 mg) or arimidex (0.5 mg) for this duration as well. Its not advised that these products be ran concomitantly with the steroid for the entire duration of the stack, as this will reduce your gains. Instead cease the usage of anti-estrogens once the problem is contained, and should the problem resurface, simply recommence the use of the products in the same manner as described above.
Once a cycle of steroids is concluded one should always initiate a post-cycle therapy to help bring back natural testosterone as soon as possible. This will help you to retain the mass you gained. How this is done depends highly on the type of steroid used. If only orals were used, therapy should start immediately, even the last day of the stack. If short-acting esters or water-based injectables were used, therapy should commence within 4-7 days after last injection, and if long-acting esters were used then it should commence 1.5 to 2 weeks after the last injection was given. The length of the therapy will vary as well, from 3-5 weeks. The longer acting the product was, the longer therapy should be continued to make sure all suppressive factors are cleared before use of Clomid/Nolvadex is discontinued.
The questions you will hear from athletes over and over is if they can get legal steroids clomid and nolvadex, is it possible?well I say yes you just have to look.
For best results, it is best stacked with HCG (Human Chorionic gonadotrophin), which functions as an LH analog and can help bring testicle size back up. HCG use starts the last week of a cycle, and on from there every 5-6 days (usually 1500-3000 IU) and discontinued 1.5 to weeks prior to the cessation of Nolvadex/clomid. The reason being that HCG itself is also suppressive of natural testosterone and should be out of the body before therapy is over, or it will inhibit natural testicle function. But I can not stress enough that HCG possibly plays a more important role in post-cycle therapy than clomid/Nolvadex. For Clomid and Nolvadex, doses are usually tapered down. Its best to start with 40-50 mg of Nolvadex or 150 mg of Clomid for the first week or the first two weeks, and then finish the program with 20-25 mg of Nolvadex or 100 mg of Clomid for an additional two weeks.
Anabolic Steroids Profile
Andropen 275
Andropen ( Andropen 275 ) is a five-ester blend of testosterone produced by British Dragon, and is clearly an attempt to profit off of the popularity of Sustanon. Actually, if you are inclined to use blended products such as this (and personally, I´m not anymore), then I think you´ll find this to be a product far superior to Sustanon.
Andropen contains 20mgs of Testosterone Acetate, 75mgs of Testosterone Cypionate, 90mgs of Testosterone Decanoate, and 40mgs each of Testosterone Propionate and Phenylpropionate in a 20ml bottle. I am very impressed with the fact that this product appears to be designed specifically for bodybuilders and athletes, and certainly if I wanted to create a long, medium, and short estered testosterone product, it would be something like this one. Also, due to that fact, I think I´d recommend shooting it EOD, or E3D or so& .giving you a very decent and relatively stable level of hormone in your body. A few years back, I made a testosterone blend for my own use out of powders, which was essentially a five estered testosterone (the same esters as Sust + 100mgs of test with the Cypionate ester per milliliter). Anyway, now it seems that every Underground Lab is involved with this type of thing. It´s not uncommon to see a price list with several "custom blends" or "house blends" of various estered testosterone´s (or sometimes Trenbolones, or whatever).
Testosterone is a relatively cheap drug (the cheapest, actually, in terms of anabolics), and that´s why it´s not actually a bad choice for blended products. In terms of "bang for the buck", it´s a great choice, as it can do just about everything. It induces changes in both the shape as well as size as muscle fibers (1). It can change the appearance and the number of muscle fibers (1), also, which is definitely a good thing for the cosmetic athlete (read: bodybuilder). Testosterone has the profound ability to protect your muscle from catabolic (muscle wasting) glucocorticoid hormones (2), although not as well as (for example) Tren or other such (more expensive) drugs. Glucocorticoid hormones send a message to muscle cells to release stored protein, while Testosterone sends a message to muscle cells to store more contractile protein (called actin and myosin). In this way, these two hormones are at war with each other to cause anabolic vs. catabolic effects. Usually they are at a stalemate (which is why you don´t gain weight constantly, nor lose it). When you add in some Testosterone (such as Andropen 275), you shift the scales in favor of anabolism, and away from catabolism. In addition to this, Testosterone has the ability to increase erythropoiesis (red blood cell production) in your kidneys (3), and a higher Red Blood Cell (RBC) count is highly sought after by many athletes because it may improve endurance via better oxygenated blood. More RBCs can also improve recovery from strenuous physical activity, and seems to give the muscles a more "full" look when bodyfat levels are reasonably low. Agression levels often rise dramatically with the use of exogenous testosterone (9), and due to some of the short esters in Andropen 275, I´d expect this effect to become realized within the first day of injection.
All of these great benefits are to be had with the use of test enth alone, but realistically, it will be part of a cycle containing one or more other drugs. People who are bulking will probably choose Deca or Eq (possibly with Dbol as well) and those who are cutting will probably steer towards Eq and perhaps Trenbolone. Very often users will shoot this drug once or twice a week, but blood levels are still above baseline with this drug at around day eight (10).Common wisdom holds that the testosterone portion of any such cycle should be equal to or greater than any other injectable drug(s) portion (on a mg basis)& I believe that you can get away with less, but in general, this is a good guideline.
The real advantage to this product, in my opinion, over Sustanon is in its practicality. As you know, I´m not a huge fan of multi-estered products, because it seems that this gives the manufacturer carte blanche to charge whatever they want. Well, this product costs roughly $150, for a 20ml, multi use vial. When compared to buying Sustanon by the amp, you could be paying up to $50 more for the same amount of testosterone. If you are looking for a product of this nature, this is one that I would actually recommend.
This product should provide less of the watery "bloated look" that an equal amount of (for example) testosterone cypionate would give, but more than you´d get with testosterone propionate. This makes it a possible choice for use in either a bulking or cutting cycle, or the ever popular "lean mass" cycle we´re seeing lately, on Steroid.com. Of course, the usual side effects experienced with any testosterone use would be expected with this product: Acne, water-retention, gyno, etc& And so would all of the positive effects we use testosterone for: muscle Gain, fat loss, strength gain, etc&
Really, as I´ve said numerous times, the one principal drawback to using blends of testosterone tends to be their high cost as compared with single ester tests. If this product could be had cheaply, I wouldn´t hesitate to recommend it.
Testosterone + 5 esters [4-androstene-3-one, 17beta-ol] Molecular Weight of base: 288.429 Molecular Weight of Acetate ester: 60.0524 Molecular Weight of Propionate ester: 74.0792 Molecular Weight of Phenylpropionate ester: 150.174 Molecular Weight of Cypionate ester: 132.1184 Molecular Weight of Decanoate ester: 172.2668 Formula (base): C19 H28 O2 Formula of Acetate ester: C2 H4 O2 Formula of Propionate ester: C3H6O2 Formula of Phenylpropionate ester:C9 H10 O2 Formula of Cypionate ester: C8 H14 O2 Formula of Decanoate ester: C10 H20 O2 Manufacturer: British Dragon Effective dose (injectable): (Men) 550mgs-1,100mgs+/week Active Life: 14 days Detection Time: 3 months (projected) Anabolic/Androgenic Ratio (Range):100:100 References:
Anat Histol Embryol. 2003 Apr;32(2):70-9. J Lab Clin Med. 1995 Mar;125(3):326-33. Zhonghua Nan Ke Xue. 2003;9(4):248-51 J Clin Endocrinol Metab. 2003 Apr;88(4):1478-85 J Clin Endocrinol Metab. 2004 Feb;89(2):718-26. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52. Biochim Biophys Acta. 1995 May 11;1244(1):117-20. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81. Health Psychol. 1990;9(6):774-91. Fertility and Sterility 33. |
ViagraSildenafil citrate, sold under the names Viagra.Viagra pills are blue and diamond-shaped with the words "Pfizer" on one side and "VGR xx" (with xx representing 25, 50 or 100, the dose of that pill in milligrams) on the other. Its primary competitors on the market are tadalafil (Cialis), and vardenafil (Levitra).
As with all prescription drugs, proper dosage is at the discretion of a licensed medical doctor. The dose of sildenafil is 25 mg to 100 mg taken once per day between 30 minutes to 4 hours before sexual intercourse.
It is usually recommended to start with a dosage of 50 mg and then lower or raise the dosage as appropriate. The drug is sold in three dosages (25, 50, and 100 mg).
Contraindications include:
When taking nitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate, sodium nitroprusside, amyl nitrite ("poppers")
In men for whom sexual intercourse is inadvisable due to cardiovascular risk factors
Severe hepatic impairment (decreased liver function)
Severe impairment in renal function
Hypotension (low blood pressure)
Recent stroke or heart attack
Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases)
Amongst sildenafil's serious adverse effects are: priapism, severe hypotension, myocardial infarction, ventricular arrhythmias, sudden death, stroke and increased intraocular pressure.
Common side effects include sneezing, headache, flushing, dyspepsia, prolonged erections, palpitations and photophobia. Visual changes including blurring of vision and a curious bluish tinge have also been reported.
Care should be exercised by patients who are also taking Protease inhibitors for the treatment of HIV. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side-effects. It is recommended that patients using protease inhibitors limit their use of sildenafil to no more than one 25-mg dose every 48 hours.
Some Viagra users have complained of blurriness and loss of peripheral vision.
A small number of men have lost eyesight in one eye some time after taking Viagra, Cialis, or Levitra. This type of vision loss is called non-arteritic anterior ischemic optic neuropathy (NAION). NAION causes a sudden loss of eyesight because blood flow is blocked to the optic nerve.
We do not know at this time if Viagra, Cialis, or Levitra causes NAION. NAION also happens in men who do not take these medicines. People who have a higher chance for NAION include those who:
have heart disease
over 50 years old
have diabetes
have high blood pressure
have high cholesterol
smoke
have certain eye problems
XenicalBrand name for orlistat, Xenical is a wonder drug for people suffering with obesity and fat related syndromes. A potent member of Lipase inhibitor group of drugs, Xenical helps reduce unwanted weight and also maintain the sliced weight from rising up the scales again. Xenical stops the human digestive system from digesting and absorbing certain fat taken through food. This, however, nullifies the chances of calories settling down on the body. Xenical can show results only when it is taken in with controlled and fat free diet. The most beneficial part of Xenical is that it doesn't stop working after it has reduced the weight. It is equally active in maintaining the lowered weight and thus protects the body from getting affected with other obesity related syndromes. Although much safer from other weight reducing drugs available in the market, Xenical has many side effects. So it is in the interest of the users to take this drug regularly on time for the best results.
Xenical Warnings
The effectiveness and dosage of Xenical may vary from person to person depending on the health conditions. Let your doctor know if you are allergic to any Lipase Inhibitor or Xenical in particular. Also don't forget to mention if you are already suffering from any of the following diseases:
High Blood Sugar;
Chronic mal-absorption syndrome;
Gallbladder problems;
Kidney stones;
Anorexia;
Bulimia.
Enlisted in FDA pregnancy category B, Xenical is not expected to cause any severe damage to growing foetus. This drug has not yet been studied on pregnant women, but cause reduction in the amount of vitamins absorbed by our body through food. It is not known whether Xenical passes into mother's breast milk or not. However, women should always consult a doctor before taking up Xenical during pregnancy or breast-feeding stage.
Xenical have not been tested on children and older adults so far. Doctors are, however, not suspecting any harmful effects of this drug on children and aged individuals.
Xenical may not work at its best with all other OTC or prescribed drugs. So it is recommended to tell your doctor before hand if you are taking any of the following drugs before taking up Xenical:
Neoral;
Sandimmune;
Coumadin;
Lipitor;
Baycol;
Lescol;
Mevacor;
Pravachol;
Zocor.
Xenical Side Effects
Intake of Xenical is followed by the appearance of a host of side effects. Although side effects disappear within 2 to 3 days of usage, it is always safer to consult a doctor immediately after the side effects start surfacing. The serious side effects of Xenical include breath trouble, closed throat, swollen lips, tongue, or face etc.
Side effects like fever, body ache, cough, headache, running nose, sneezing, sore throat gas formation with loose motion, oily stool discharge, orange or brown colored oil in your stool are very common and less harmful. . .
Among the uncommon side effects of Xenical, blood in urine, hearing difficulty, urination problem, dental problem, sudden tension, change in menstrual cycle, rectal pain and uneasiness are notable.
Xenical Overdose
So far no cases of Xenical overdose with fatal consequences have been reported. However, prevention is always better than cure. Avoid taking double dose and rush to a doctor immediately after you realize that you have taken a double dose. This is more important as nothing is known about the normal symptoms of Xenical overdose.
Missed dose of Xenical may not be much harmful. Take the missed dose within one hour after a meal. And if you don't remember within 1 hour just skip the last dose and go for the next scheduled one. Be very careful not to take a double dose.
Xenical Usage Guidelines
Rely on your doctor for the best usage guidelines. Normally Xenical is taken in with a full glass of water. Xenical is taken within one hour of the main meal. Make sure not to include more than 30% of fat in your meal. As Xenical may reduce vitamin absorption power of the body, be very careful and particular about taking vitamin supplements prescribed by the drug. Store Xenical at room temperature for best results.
SolcoserylSolcoseryl Jelly:
Skin and mucous tunic regenerating action. Indications: burns, ulcers and venous insufficiency.
Solcoseryl® Jelly:Suitable for wet wounds.
Apply Solcoseryl® Jelly 2-3 times a day until fresh skin tissue has formed. Improves metabolism and accelerates the regeneration of the tissue in cases of surface ulcers.
Contains:
Free of protein extract of cattle blood.
To date no side effects have been observed. After application of Solcoseryl® Jelly an unpleasant stinging may occur for a short time.
Solcoseryl® Ointment:
Suitable for dry wounds. Continue with Solcoseryl® Ointment to obtain complete epithlisation.
Solcoseryl ointment:
Solkoseril is an extract of the cattle blood, but is free of protein. This product improves the metabolism and accelerates of the regeneration of the tissue in cases of surface ulcers caused by oxygen deprivation, gangrene, bedsores, burns, radiation ulcers, and skin grafts.
Recommended dosage:
In cases of bedsores apply gel until a scab emerges and then use ointment until the new skin surface appears. For burns use either gel or ointment. Normal course of treatment depends on the body's healing process, but usually lasts from 4 to 8 weeks. Use of the gel may irritate or burn the skin, but these side effects do not require interruption of therapy.
RoaccutaneHow does it work?
Roaccutane capsules contain the active ingredient isotretinoin. (NB. Isotretinoin capsules are also available without a brand name, ie as the generic medicine.) Isotretinoin belongs to a group of medicines known as retinoids, which are derivatives of vitamin A. Isotretinoin taken by mouth works by reducing the production of the skin's natural oil (sebum).
Acne occurs due to an excessive production of sebum from over-active sebaceous glands in the skin. The sebum blocks the sebaceous glands, which prevents the oil from flowing freely out and causes an accumulation of sebum under the skin. The bacteria associated with acne thrive in these conditions. They feed on the sebum, and produce waste products and fatty acids that irritate the sebaceous glands, making them inflamed and causing spots.
Isotretinoin decreases the size and activity of the sebaceous glands in the skin, which reduces the amount of sebum that is produced. This stops the glands becoming blocked, and means bacteria are less likely to thrive. It also reduces the inflammation in the skin.
Isotretinoin can have serious side effects and its use must be supervised by a dermatologist. It is reserved for the treatment of severe acne (such as nodular or conglobate acne or acne at risk of permanent scarring) that has not improved with standard treatment involving oral antibiotics and topical medicines.
Your acne may worsen at the start of treatment, but this usually subsides within 7 to 10 days of continued treatment. In most cases, complete or near-complete clearing of acne is achieved with a 12 to 16 week course of treatment, and you are likely to remain free of acne for a long time. Repeat courses are not normally recommended, unless a definite relapse is seen after treatment is stopped. Repeat courses should not be started until at least eight weeks after stopping treatment, as your acne may still improve in this time.
What is it used for?
Severe acne that has not responded to standard treatment with oral antibiotics and topical medicines.
Warning!
Isotretinoin causes major birth defects (serious malformations of a developing foetus) if taken during pregnancy. For this reason your doctor will not prescribe the treatment to women who could get pregnant, unless the following criteria are met: At least one, but preferably two (for example the pill and condoms), effective methods of contraception must be used at all times to prevent pregnancy. Contraception must start at least four weeks before starting treatment, be used at all times during treatment and for at least four weeks after stopping treatment, even if you don't have a period. Your doctor cannot prescribe isotretinoin until you have been using effective contraception for at least a month and have had a negative pregnancy test. Your doctor is only allowed to prescribe 30 days supply of isotretinoin at a time. You will need to have a follow-up visit every month, at which you will have to have a negative pregnancy test before a new prescription can be issued. Five weeks after stopping treatment you should have a final pregnancy test to make sure you have not fallen pregnant. If you think there is a chance you could be pregnant, either during treatment, or in the first month after stopping treatment, you must consult your doctor immediately.
There is no evidence to suggest that children fathered by men who are taking isotretinoin will be affected by the medicine, but men should remember not to give this medicine to anyone, particularly females.
You should never give this medicine to another person and you should return any unused medicine to your pharmacist at the end of treatment.
People taking this medicine must not donate blood during treatment, and for at least four weeks after stopping treatment. This is due to the potential risk of the medicine to an unborn child if the blood transfusion was received by a pregnant woman.
This medicine may cause depression, anxiety, mood changes, psychotic symptoms and rarely suicide attempts. For this reason, if you start to feel depressed, or experience any other mood changes during treatment, it is important to talk to your doctor.
You should avoid exposing your skin to intense sunlight or UV light while taking this medicine. You should use a sunscreen of at least SPF 15 when necessary.
Isotretinoin is likely to make your skin and lips very dry, so it is recommended that you use a moisturiser and lip balm from the start of treatment.
You should avoid waxing any part of your body while taking isotretinoin, and for at least six months after stopping treatment, as this could cause stripping of the top layer of skin. Chemical dermabrasion and cutaneous laser treatment should also be avoided during treatment with isotretinoin and for five to six months after stopping treatment, as this could cause scarring.
Isotretinoin can make your eyes dry. This can be relieved with artificial tear drops. Ask your doctor or pharmacist for advice. If you wear contact lenses you may find that they become uncomfortable during treatment and you have to wear glasses instead. Decreased night vision may also occur during treatment and after treatment has been stopped, and can occur suddenly. For this reason you are advised to be cautious when driving or operating any vehicle at night. If you experience any visual difficulties, inform your doctor so that your vision can be monitored. It may sometimes be necessary to stop treatment.
You will need to have a blood test to monitor your liver function before you start treatment with this medicine, one month after starting and then at further three-monthly intervals.
The amount of lipids (fats such as cholesterol) in your blood should also be monitored before treatment, one month after starting treatment and at three-monthly intervals. If your blood level of triglycerides becomes too high, your isotretinoin dose may need to be reduced and you may have to go on a low fat diet. If your triglycerides cannot be controlled, you may have to stop treatment with isotretinoin.
This medicine may increase your blood sugar level. People with diabetes may need to monitor their blood sugar more frequently during treatment with this medicine. Ask your doctor for advice.
If you experience severe bloody diarrhoea during treatment with this medicine you should stop taking it and consult your doctor immediately.
This medicine is not recommended for children under 12 years of age.
Use with caution in
Women who could get pregnant
History of depression
Decreased kidney function
Alcoholism
Diabetes
Obesity
Lipid metabolism disorders
Not to be used in
Pregnancy
Breastfeeding
Woman who could get pregnant, unless the criteria described in warnings above are met
;
Acne that has developed before reaching puberty (prepubertal acne)
Decreased liver function
High levels of fats
A condition resulting from the excessive consumption of vitamin A (hypervitaminosis A)
People taking tetracycline-type antibiotics
Peanut or soya allergy (Roaccutane capsules contain arachis oil and soya oil)
Rare hereditary problems of fructose intolerance (Roaccutane capsules contain fructose)
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Isotretinoin MUST NOT be used during pregnancy as it causes major birth defects and serious malformations of the foetus. Women who could get pregnant will only be prescribed this medicine if all the criteria listed in warnings above are met. At least one and preferably two effective methods of contraception must be used to prevent pregnancy for at least one month before starting treatment, during treatment and for at least one month after finishing treatment. If you think you could be pregnant at any point during treatment or in the month after stopping treatment you must consult your doctor immediately.
This medicine must not be used by breastfeeding mothers, as it passes into breast milk and could have adverse effects on the nursing infant. Seek medical advice from your doctor.
Label warnings
Follow the printed instructions you have been given with this medication.
Take this medication with or after food.
TempalginIndications:
Mild to moderate pain of variable origin: headache; migrene; toothache; neuralgia; neuritis; plexitis; lumbalgia; myalgia and myositis; trauma; postsurgery interventions and dental procedures; dysmenorrhoea; burning; premedication in the dental practice.
Dosage and administration:
In adults, Tempalgin is used orally in dose of 1 - 2 tablets 3 - 4 times daily. In children over 10 years, the drug is administered in dose of 1 tablet 2 - 3 times daily. The treatment course duration should not exceed 5 to 7 days.
Contraindications:
Hypersensitivity to tempidon, metamizole and other pyrazolone drugs; acute hepatic porphyria and inborn deficiency of glucose-6-phosphate dehydrogenase; aplastic anemia, leucopenia and agranulocytosis; severe kidney and liver diseases; pregnancy; children younger than of 10 years.
Special warnings and precautions:
The drug is used cautiously in patients suffering from liver or kidney diseases. After more prolonged treatment with Tempalgin regular checks of blood count are necessary. In patients suffering from bronchial asthma, pollinosis, Quincke's edema, chronic airway infections or showing hypersensitivity to analgesic and nonsteroidal anti-inflammatory agents, as well as to other drugs or foods, there is a risk of allergic reactions and asthmatic attacks. During lactation the drug should be avoided, because both active ingredients are eliminated in the breast milk. Tempidon decreases the attention concentration and slows the reflexes. Because of this it should be used cautiously in car drivers and in people working with machines.
Drug interactions:
Because of the inhibition of hepatic enzyme systems metabolising drugs, Metamizole effect is potentiated by tricyclic antidepressants (psychophorin, amitriptyline), oral contraceptive agents, and allopurinol. Due to this its biotransformation is slower, and the toxicity is greater. Barbiturates and phenylbutazone are liver enzyme inductors, and they decrease the strength and duration of the metamizole pharmacodynamic effect. Metamizole lowers the plasma cyclosporin levels. Chloramphenicol increases the myelotoxic action of metamizole (additive effect). Alcohol augments the action of both components. Tempidon potentiates the activity of the hypnotic agents, general anesthetics, and narcotic and nonnarcotic analgesics.
Adverse reactions:
Itching, skin rash, urticaria, Stevens-Johnson's syndrome, Layell's syndrome, angioedema, vasomotor disturbances; asthmatic attack, allergic shock; nausea, vomiting, abdominal pain and discomfort, ulcers and bleeding in rare cases. In susceptible patients, agranulocytosis, leucopenia, aplastic anemia, retention of water and electrolytes are possible.
AnalginAnalgin tablets are used for the treatment of pains of different origin and variable intensity: toothache, headache, arthralgia, neuralgia, myositis, mild to moderate visceral pain, high fever, not responding to other drugs.
Analgin is used with increased caution in patients with a history for hypersensitivity to foods and drugs (particularly to analgesic and nonsteroidal antiinflammatory agents) and also in patients suffering from bronchial asthma, Quincke's edema, chronic pulmonary infections. In patients with hypotension and unstable blood pressure, Analgin should not be used parentarally. If Analgin application is quite necessary, the blood pressure and the heart rate should be monitored. In cases of prolonged Analgin treatment, regular blood count checks are necessary (differential count of the white blood cells). The high Analgin doses can influence unfavourably the active attention. Because of this in these cases driving and working with machines are not advised.
Analgin potentiates the analgesic and antipyretic action of the nonsteroidal antiinflammatory drugs. The Analgin effects are potentiated by the tricyclic antidepressants, oral contraceptive agents, allopurinol, alcohol. Analgin decreases the activity of the coumarin anticoagulants and plasma levels of cyclosporin. The enzyme inductors (barbiturates, glutethimide, phenylbutazone) attenuate the Analgin effects. Analgin potentiates the effects of the drugs possessing CNS depressant activity. Concurrent administration with chlorpromazine is related with a risk of severe hypothermia. Analgin can be used in combination with buscolysin, atropin, codein.
PregnylDescription
Chorionic gonadotropin (kor-ee-ON-ik goe-NAD-oh-troe-pin) is a drug whose actions are almost the same as those of luteinizing (loo-te-in-eye-ZING) hormone (LH), which is produced by the pituitary gland. It is a hormone also normally produced by the placenta in pregnancy. Chorionic gonadotropin has different uses for females and males.
In females, chorionic gonadotropin is used to help conception occur. It is usually given in combination with other drugs such as menotropins and urofollitropin. Many women being treated with these drugs usually have already tried clomiphene alone (e.g., Serophene) and have not been able to conceive yet. Chorionic gonadotropin is also used in fertilization (IVF) programs.
In males, LH and chorionic gonadotropin stimulate the testes to produce male hormones such as testosterone. Testosterone causes the enlargement of the penis and testes and the growth of pubic and underarm hair. It also increases the production of sperm.
Although chorionic gonadotropin has been prescribed to help some patients lose weight, it should never be used this way. When used improperly, chorionic gonadotropin can cause serious problems.
Chorionic gonadotropin is to be administered only by or under the immediate supervision of your doctor. It is available in the following dosage form:
Parenteral
Injection (U.S. and Canada)
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For chorionic gonadotropin, the following should be considered:
Allergies - Tell your doctor if you have ever had any unusual or allergic reaction to chorionic gonadotropin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy - If you become pregnant as a result of using this medicine with menotropins (e.g., Pergonal) or urofollitropin (e.g., Metrodin), there is an increased chance of a multiple pregnancy (for example, twins, triplets).
Children - Chorionic gonadotropin, when used for treating cryptorchidism (a birth defect where the testes remain inside the body), has caused the sexual organs of some male children to develop too rapidly.
Other medicines - Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems - The presence of other medical problems may affect the use of chorionic gonadotropin. Make sure you tell your doctor if you have any other medical problems, especially:
Asthma or
Epilepsy (seizures) or
Heart problems or
Kidney problems or
Migraine headaches - This medication may worsen these conditions.
Cancer of the prostate or
Precocious puberty (a condition that causes early puberty in boys before 9 years of age) - Increases in the amount of testosterone in the bloodstream may make these conditions worse.
Cyst on ovary or
Fibroid tumors of the uterus - Chorionic gonadotropin can cause further growth of cysts on the ovary or fibroid tumors of the uterus
Unusual vaginal bleeding - Irregular vaginal bleeding is a sign that the endometrium is growing too much, of endometrial cancer, or of other hormone imbalances; the increases in estrogen production caused by ovulation can aggravate these problems of the endometrium. If other hormone imbalances are present, they should be treated before beginning ovulation induction
Proper Use of This Medicine
Dosing - The dose of chorionic gonadotropin will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses for chorionic gonadotropin. If your dose is different, do not change it unless your doctor tells you to do so.
The number of doses you receive each day, the time allowed between doses, and the length of time you receive the medicine depend on the medical problem for which you are receiving chorionic gonadotropin.
For injection dosage form:
For treating men with problems related to low levels of male hormones:
Adults - 1000 to 4000 Units injected into the muscle two to three times a week. You may need to receive this medicine for several weeks, months, or longer. If you are being treated for a low sperm count and have been on this medicine for six months, your doctor may give you another hormone medicine (menotropin or urofollitropin injection). You may need to receive both of these medicines together for up to twelve more months.
To help pregnancy occur in women:
Adults - 5000 to 10,000 Units injected into the muscle on a day chosen by your doctor. The dose and day will depend on your hormone levels and the other medicines that you have been using.
For the treatment of cryptorchidism (condition where testes do not develop properly):
Children - 1000 to 5000 Units injected into the muscle two to three times a week for up to ten doses.
Precautions While Using This Medicine
It is very important that your doctor check your progress at regular visits to make sure that the medicine is working and to check for unwanted effects.
For women taking this medicine to become pregnant :
Record your basal body temperature every day if told to do so by your doctor, so that you will know if you have begun to ovulate. It is important that intercourse take place around the time of ovulation to give you the best chance of becoming pregnant. Your doctor will likely want to monitor the development of the ovarian follicle(s) by measuring the amount of estrogen in your bloodstream and by checking the size of the follicle(s) with ultrasound examinations.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some other effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
For females only
More common
Bloating (mild); stomach or pelvic pain
Less common or rare
Abdominal or stomach pain (severe); bloating (moderate to severe); decreased amount of urine; feeling of indigestion; nausea, vomiting, or diarrhea (continuing or severe); pelvic pain (severe); shortness of breath; swelling of feet or lower legs; weight gain (rapid)
For boys only
Less common
Acne; enlargement of penis and testes; growth of pubic hair; increase in height (rapid)
Frequency not determined
difficult or labored breathing; difficulty breathing; flushing of skin; hives or welts; itching of skin; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; pain in chest, groin, or legs, especially the calves; redness of skin; severe, sudden headache; skin rash; slurred speech; sudden loss of coordination; sudden, severe weakness or numbness in arm or leg; sudden, unexplained shortness of breath; tightness in chest; unusually warm skin; vision changes; wheezing
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Less common
Discouragement; enlargement of breasts; feeling sad or empty; headache; irritability; lack of appetite; loss of interest or pleasure; pain at place of injection; trouble concentrating; trouble sleeping; tiredness
After you stop receiving this medicine, it may continue to cause some side effects which require medical attention. During this period of time check with your doctor if you notice any of the following side effects:
For females only
Less common or rare
Abdominal or stomach pain (severe); bloating (moderate to severe); decreased amount of urine; feeling of indigestion; nausea, vomiting, or diarrhea (continuing or severe); pelvic pain (severe); shortness of breath; weight gain (rapid)
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
StimolSTIMOL (citrulline malate) - oral solution in sachets
Composition of the medicine:
Active ingredient: one sachet contains 50 % citrulline malate solution 2,0 g;
Excipients: purified water, natural sangria orange flavor, NaOH (for pH adjustment).
Pharmaceutical form. Oral solution.
Pharmacotherapeutic group.
Metabolism corrector to treat asthenia. The product belongs to amino acids.
Stimol utilizes lactate, ammonium, stimulates energy release, brings the cell to another energetic level.
Indications:
Symptomatic treatment of functional asthenia :
physical asthenia;
mental asthenia;
post-infectious asthenia:
postoperative asthenia;
asthenia during pregnancy;
senile asthenia,
asthenia of endocrinology origin (diabetic);
sportsmen's asthenia (muscle pain relief after the intensive training);
asthenia and vegetative syndrome by vegetal and vascular dystonia hypotonic type;
alcohol withdrawal syndrome;
sexual asthenia.
Administrate in case of the following symptoms of asthenia: general weakness, emotional lability, chronic tiredness, low capacity for work, drowse. It is recommended to administrate Stimol in case of muscular pain and cramps, resulting from the accumulation of lactate after the heavy training. This product is
recommended for the period of convalescence.
Contra-indications:
Hypersensitivity to any of the component of the product. Stomach and duodenal ulcer.
Warnings:
One sachet contains about 30 mg (1,3 mmol) of sodium to make pH solution 3,3. It must be taken into the account for patients with a salt free diet.
Interactions with other drugs: Not observed.
Methods of administration and dosage:
Children over 6 years: 1 sachet 2 times per day.
Adult and elderly people: 1 sachet 3 times per day.
Recommended duration of treatment - 4 weeks.
Stimol should be taken during meals. The content of sachet should be diluted up to 100 ml by water or sweetened beverages.
Side effects:
Several cases of discomfort in epigastrium without cancellation of administration. Point out to your physician every undesirable effect.
Shelf-life: 3 years.
Do not administrate after expiry date indicated on the box.
Storage conditions: Store at room temperature ( + 15-25°C), keep away from reach of children.
Packing: 18 sachets in aluminum and polyethylene paper in carton box.
Delivery conditions: Without prescription.
Synvisc This product is temporary out of stock, but if you want it, please let us know, we will contact our supplier and send you the medication you need ASAP.
Synvisc is a safe treatment for early osteoarthritis of the knee. While not proven to be a long-term solution, this may improve symptoms and delay the need for surgical treatment of knee osteoarthritis. Synvisc is ONLY approved for use in the knee joint. Treatments are safely and easily performed, and there are few-side effects.
Successful treatment with Synvisc can help reduce osteoarthritis knee pain, which can lead to increased mobility. Pain relief can last for up to 6 months. While you may begin to feel some relief right away, most patients feel greatest pain relief 8 to 12 weeks after beginning treatment.
SYNVISC is generally well tolerated. However, it may not work for everyone.
The side effects most commonly seen when SYNVISC is injected into the knee were pain, swelling and/or fluid build-up around the knee. Cases where the swelling is extensive or painful should be discussed with your doctor. Other side effects such as rash have been reported rarely. Before trying SYNVISC, tell your doctor if you are allergic to products from birds - such as feathers, eggs, or poultry - or if your leg is swollen or infected.
SYNVISC has not been tested in children, pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.
Humulin RegularWARNINGS:
THIS LILLY HUMAN INSULIN PRODUCT DIFFERS FROM ANIMAL-SOURCE INSULINS BECAUSE IT IS STRUCTURALLY IDENTICAL TO THE INSULIN PRODUCED BY YOUR BODY'S PANCREAS AND BECAUSE OF ITS UNIQUE MANUFACTURING PROCESS.
ANY CHANGE OF INSULIN SHOULD BE MADE CAUTIOUSLY AND ONLY UNDER MEDICAL SUPERVISION. CHANGES IN STRENGTH, MANUFACTURER, TYPE (E.G., REGULAR, NPH, LENTE®), SPECIES (BEEF, PORK, BEEF-PORK, HUMAN), OR METHOD OF MANUFACTURE (rDNA VERSUS ANIMAL-SOURCE INSULIN) MAY RESULT IN THE NEED FOR A CHANGE IN DOSAGE.
SOME PATIENTS TAKING HUMULIN®(HUMAN INSULIN, rDNA ORIGIN) MAY REQUIRE A CHANGE IN DOSAGE FROM THAT USED WITH ANIMAL-SOURCE INSULINS. IF AN ADJUSTMENT IS NEEDED, IT MAY OCCUR WITH THE FIRST DOSE OR DURING THE FIRST SEVERAL WEEKS OR MONTHS.
Humulin is synthesized in a special non-disease-producing laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for human insulin production. Humulin R (regular human insulin injection [rDNA origin]) consists of zinc-insulin crystals dissolved in a clear fluid. Humulin R has had nothing added to change the speed or length of its action. It takes effect rapidly and has a relatively short duration of activity (4 to 12 hours) as compared with other insulins. The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with all insulin preparations, the duration of action of Humulin R is dependent on dose, site of injection, blood supply, temperature, and physical activity. Humulin R is a sterile solution and is for subcutaneous injection. It should not be used intramuscularly. The concentration of Humulin R is 100 units/mL (U-100).
Identification
Human insulin by Eli Lilly and Company has the trademark Humulin and is available in 6 formulations - Regular (R), NPH (N), Lente (L), Ultralente® (U), 50% Human Insulin Isophane Suspension [NPH]/50% Human Insulin Injection [regular] (50/50), and 70% Human Insulin Isophane Suspension [NPH]/30% Human Insulin Injection [regular] (70/30). Your doctor has prescribed the type of insulin that he/she believes is best for you. DO NOT USE ANY OTHER INSULIN EXCEPT ON HIS/HER ADVICE AND DIRECTION.
Always check the carton and the bottle label for the name and letter designation of the insulin you receive from your pharmacy to make sure it is the same as that your doctor has prescribed.
Always examine the appearance of your bottle of insulin before withdrawing each dose. Humulin R is a clear and colorless liquid with a water-like appearance and consistency. Do not use if it appears cloudy, thickened, or slightly colored or if solid particles are visible. Always check the appearance of your bottle of insulin before using, and if you note anything unusual in the appearance of your insulin or notice your insulin requirements changing markedly, consult your doctor.
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